Figure 3.

Invading ameboid-like cells are associated with a subpopulation of amyloid deposits. A, Neocortical plaque load (%) of the APP23 mice of group 1 was stereologically estimated and correlated with the number of invading ameboid-like GFP-positive cells. Results indicate a positive relationship between plaque load and number of invading cells, although the correlation did not reach statistical significance. B, Similarly, correlative analysis between CAA frequency and ameboid cell count revealed a positive trend. C, Photomicrograph exemplifying the heterogeneous distribution of invading peripheral cells in relation to amyloid plaques. Some plaques were surrounded by a high number of invading cells, whereas neighboring plaques completely lacked invading peripheral cells. The amyloid is stained with Congored, and GFP-immunopositive cells are represented in black. Scale bar, 75 μm.