Skip to main content
. 2005 Oct 12;25(41):9321–9327. doi: 10.1523/JNEUROSCI.2936-05.2005

Figure 7.

Figure 7.

AAV4βgluc reverses behavioral deficits in MPS VII mice in context fear-conditioning assays. One-way ANOVA revealed group (n = 3, heterozygous, treated, and untreated MPS VII mice) as a significant factor (F(2,220) = 10.754; p < 0.0001). A, Baseline measurements in context 1, day 1. Both treated and untreated MPS VII mice have significant elevated baseline levels of freezing compared with heterozygous controls (*p < 0.0001; Fisher's PLSD). B, The increase in freezing time from baseline after placement in context 1 on day 2. Results from treated MPS VII mice and heterozygotes are comparable (p = 0.63; Fisher's PLSD). Increases in freezing time for untreated MPS VII mice were significantly less than the other groups (*p < 0.0001; Fisher's PLSD). C, Difference in freezing time between context 1 and 2, day 2. Compared with untreated MPS VII mice, treated MPS VII mice and heterozygous controls freeze significantly less in context 2 compared with context 1 (*p < 0.0001; Fisher's PLSD). Error bars represent SEM.