Figure 2.

NRG-1β-mediated LTP reversal shares similarities with activity-dependent depotentiation. A, B, NRG-1β reverses LTP in a time-dependent manner. Insets as in Figure 1. Slices were perfused with NRG-1β for 30 min (A) and 50 min (B) after TBS (arrow) (n = 7 and 8, respectively). C, D, TPS-induced depotentiation is blocked by ErbB receptor inhibition. C, TPS (arrowhead) blocks LTP induced in the S1 pathway (•) and has no effect on the S2 pathway (○) (n = 5). D, PD158780 (10 μm; gray bar) was added immediately after S1 stimulation (•) (n = 6). Data are expressed as mean ± SEM.