Figure 4.

Waves emerge in the KO region by P5. A, Rasters from 10 simultaneously recorded multiunit spike trains. Correlated bursting is present in both littermate controls and in pieces of retina containing only the ChAT-negative region of ChAT^r-/r-;Z/EG retinas. B, Examples of waves recorded by the multielectrode array from a wt littermate and from a KO region in the ChAT^r-/r-;Z/EG retina. Each dot represents an electrode site and the multiunit firing rate (averaged over 0.5 s) recorded at that site is proportional to the radius of the dot. Electrode spacing is 100 μm. C, Distributions of interwave intervals, calculated using the surprise algorithm (see Materials and Methods). D, Distributions showing the number of coactive electrodes. E, Plots of correlation index versus interelectrode distance for pairs of multiunit spike trains. Plotted are median values, and bars extend from the 25th to the 75th percentile.