Figure 6.

Excitatory terminals onto POMC neurons respond only to exogenous cannabinoids. Evoked excitatory PSCs were not altered by AM 251 in POMC cells (A; p = 0.72, n = 8). WIN 55,212-2 inhibited the evoked excitatory currents in POMC neurons (B; p = 0.02, n = 8). The data represent the mean ± SEM. Three sweeps were averaged so that there is a data point for each minute. The insets show an average of three eIPSCs in control conditions (last minute of control) and in drug (between 9 and 10 min in drug). Error bars represent SEM.