Figure 1.

Characterization of motor activity in vehicle-injected and 6-OHDA-injected (hemiparkinsonian) rats. A-C, Hemiparkinsonian rats displayed overall reduction in motor activity and motor asymmetry compared with vehicle-injected rats, as shown by an increase in the total time spent on the blocks in the bar test (the contralateral forepaw being more severely affected; A), reduction in the number of steps made by the contralateral forepaw in the drag test (B), and reduced rotarod performance (C). C, The rotarod performance of naive rats has also been reported. Data are mean ± SEM of 10-33 determinations obtained from 26 vehicle-injected, 33 hemiparkinsonian, and 18 naive rats. °°p < 0.01 versus the ipsilateral forepaw. ^##p < 0.01 versus vehicle-injected and naive rats (ANOVA followed by Newman-Keuls post hoc test). Error bars represent SEM.