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. 2005 Oct 19;25(42):9591–9601. doi: 10.1523/JNEUROSCI.2546-05.2005

Figure 9.

Figure 9.

Deletion of the ppN/OFQ gene attenuates the MPTP-induced loss of TH immunoreactivity in the dorsolateral CP. Density of TH immunoreactivity in the rostral (1.10 mm from bregma) CP. No significant difference was detected between saline-treated wild-type (+/+) or knock-out (-/-) mice (2.39 ± 0.17 and 2.75 ± 0.30, respectively). For comparison purposes, all saline-treated animals were combined and termed control. A, B, MPTP produced a significant loss of TH staining in the dorsolateral (A), but not ventral (B), portion of the CP. MPTP significantly decreased TH staining in the dorsolateral CP of ppN/OFQ+/+ (n = 8), but not ppN/OFQ-/- (n = 7), mice. Representative images of the CP sections from saline- and MPTP-treated mice are also presented. *p < 0.05 versus control (ANOVA followed by Newman-Keuls post hoc test). Error bars represent SEM.