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Impact of systemic challenge with LPS on CNS acute phase reactant transcription expression in ME7 and NBH animals. PTX3 (a), α2-AP (b), C3 (c), and SAA (d) mRNA were all increased by peripheral LPS injection, but only PTX3 showed a statistically significant increase in the ME7+LPS group relative to NBH+LPS. All data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ANOVA. NBH+LPS, n = 4; ME7+saline, ME7+LPS, n = 5. Sal, Saline.
