Figure 7.

Antagonistic effect of Colivelin on neuronal death in the CA1 induced by direct hippocampal injection of Aβ1-42. Coronal sections of the hippocampal CA1 regions of mice injected with 300 pmol of Aβ1-42 in the presence or absence of rescue factors (100 pmol each) were stained with cresyl violet (n = 2). Rescue factors were intracerebroventricularly injected 16 h before Aβ1-42 injection. Top left, Control; top middle, 300 pmol of Aβ1-42; top right, 300 pmol of Aβ1-42 plus 100 pmol of Colivelin; bottom left, 300 pmol of Aβ1-42 plus 100 pmol of AGA-(C8R)HNG17; bottom right, 300 pmol of Aβ1-42 plus 100 pmol of ADNF plus 100 pmol of AGA-(C8R)HNG17. Scale bars, 100 μm.