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. 2005 Nov 2;25(44):10188–10197. doi: 10.1523/JNEUROSCI.3560-05.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/2510188-10.00/0

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Figure 3. — Analysis of purified recombinant neurexin 1 α and CL 1 proteins expressed in COS-7 cells. A, Domain structure of neurexin 1α and location of Ig fusion proteins used for binding to α-latrotoxin. Principal features of neurexin 1α are indicated on the top as follows: SP, signal peptide; LNS, LNS domains; EGF, epidermal growth factor-like sequences; CHO, carbohydrate attachment site; T, transmembrane region. B, Domain structure of CL1 and location of Ig fusion protein used for binding to α-latrotoxin. SP, signal peptide; lectin, lectin-like domain; olfactomedin, a domain homologous to olfactomedins and myocilin. Close to the membrane is a cysteine-rich domain that contains a cleaving site. C, Purified recombinant neurexin 1α (the fifth and the sixth LNS domains; IG-N1α-31) was analyzed with the control protein (IG-C) by SDS-PAGE and Coomassie staining. D, Analysis of the recombinant, entire extracellular domain of CL1 (IG-CL1-1) by SDS-PAGE and Coomassie staining. HC, Heavy chain; LC, light chain.