Table 1.
Evaluation of injection size and location
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Movements evoked within the injection core |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hand (%) |
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| Group |
Case |
M1 hand area (mm2) |
PMv hand area (mm2)a
|
Injection area (mm2) |
Injection size category |
No response (%) |
Proximal (%) |
Wrist/forearm |
Digits |
Total |
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| Control | 1934 | 14.97 | 5.15 | 3.33 | Largeb | 1.2 | 13.5 | 68.5 | 16.8 | 85.3 | ||||
| Control | 1892 | 12.87 | 3.98 | 1.93c | Large | 0 | 32.1 | 5.7 | 62.2 | 67.9 | ||||
| Control | 9409 | 8.51 | 3.77 | 0.87 | Small | 0 | 16.2 | 13.7 | 70.1 | 83.8 | ||||
| Control | 3024 | 14.04 | 3.54 | 0.84 | Small | 11.9 | 0 | 54.8 | 33.3 | 88.1 | ||||
| Experimental | 21B | 0.75 | 5.08 | 1.06 | Small | 0 | 3.8 | 47.2 | 49.0 | 96.2 | ||||
| Experimental | 367E | 4.12 | 2.90 | 4.31 | Large | 36.5 | 30.1 | 22.7 | 10.7 | 33.4 | ||||
| Experimental | 1662 | 1.15 | 3.86 | 0.34 | Small | 0 | 0 | 84.2 | 15.8 | 100 | ||||
| Experimental |
9406 |
0.46 |
3.71 |
1.74 |
Large |
0 |
8.0 |
2.9 |
89.1 |
92.0 |
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Note the high individual variability in the absolute size of PMv (and other motor) maps. Thus, it is not readily apparent that the size of the PMv differs between groups. However, when the PMv hand area of each animal was compared before and after the lesion (paired comparisons), there was a significant difference between the groups in the amount of increase in total hand area (Frost, et al., 2003). On average, the increase in hand representation of PMv for the experimental group in the present study was 35.3 ± 22.6%.
The injections are large compared with others in the current study. However, they are relatively small compared with most other cortical connectivity studies.
Number is approximate because a portion of the injection core was absent (see Materials and Methods).