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. 2005 Nov 16;25(46):10637–10647. doi: 10.1523/JNEUROSCI.3279-05.2005

Figure 10.

Figure 10.

Assessment of motor function in rTg(tauP301L)4510 mice. Direct assessment of motor ability was measured by analysis of swim speed during each phase of behavioral testing. A-C, Mean swim speeds for mice aged 1.3 months and for mice tested longitudinally from 2.5 to 9.5 months during the visible, hidden, and probe trials, respectively. Age versus transgene RMANOVA data are as follows: A, F(3,99) = 31.33, p <0.0001; B, F(3,99) = 14.03, p <0.0001; C, F(3,99) = 16.30, p <0.0001. Older rTg(tauP301L)4510 mice at 9. 5 months of age didnot achieve the mean swim speed recorded in tau-negative controls until the final 10 s of probe trials (D, E; transgene RMANOVA, 9.5 months: F(1,33) = 19.74, p < 0.0001), an effect that was associated with a longer latency to begin swimming (F; age versus transgene RMANOVA: F(3,99) = 47.55, p < 0.0001; tau-positive age RMANOVA: F(3,24) = 18.87, p < 0.0001); age versus transgene RMANOVA: F(3,99) = 47.55, p < 0.0001). Data for 1.3-month-old mice [n = 31 control and n = 10 rTg(tauP301L)4510] and 2.5- to 9.5-month-old mice [n = 26 control and n = 9 rTg(tauP301L)4510] are shown. #p < 0.05, ⋄p < 0.01, *p < 0.001, **p < 0.0001. neg, Negative; pos, positive.