Figure 1.

Postsynaptic PF-LTP is PKC independent. A, PF-LTP can be induced by PF stimulation at 1 Hz for 5 min (n = 11). Each data point represents the average of three successive test responses evoked at 0.05 Hz. The top traces show EPSCs before and after LTP induction. B, Paired-pulse facilitation ratio (EPSC2/1) obtained from a subset of the LTP cells shown in A (n = 7). C, Neither the PKC inhibitor chelerythrine (10 μm; n = 7) nor the general kinase inhibitor H-7 (50 μm; n = 7) blocks LTP induction. D, In the absence of tetanization, neither chelerythrine (n = 5) nor H-7 (n = 6) affects EPSC amplitudes. The bars in C and D indicate the presence of the drugs in the bath. Error bars are mean ± SEM.