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. 2005 Nov 16;25(46):10768–10772. doi: 10.1523/JNEUROSCI.2876-05.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/2510768-05.00/0

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Figure 4. — PF-LTD is not phosphatase dependent. A, PF-LTD can be induced after paired PF + CF stimulation at 1 Hz for 5 min (n = 8). The top traces show EPSCs before and after LTD induction. B, PF-LTD is not impaired when microcystin LR (10 μm) is added to the pipette saline (n = 9). PF-LTD was blocked in the presence of chelerythrine (10 μm; n = 5) and H-7 (50 μm; n = 6), respectively. C, When active calcineurin is added to the pipette saline (5 μg/ml), paired PF + CF stimulation no longer causes a depression (n = 8), whereas PF-LTP induction is unaffected (n = 8). D, In the absence of tetanization, adding calcineurin does not affect EPSC amplitudes (n = 7). Error bars are mean ± SEM.