Table 1.
Modification of choroid plexus megalin activity in rodent models of cognitive impairment and its effect on Aβ levels, Hpf-tau, and cognition
|
Model |
Megalin |
Aβ1-40* |
Aβ1-42* |
Hpf-tau* |
Cognition** |
|---|---|---|---|---|---|
| APP/PS1 plus miniMeg | ↑ | = | = | ↓ | ↑ |
| Old rat plus miniMeg | ↑ | ↓ | = | ↓ | = |
| LID plus miniMeg | ↑ | ↓ | = | ↓ | ↑ |
| APP/PS1 plus siMeg |
↓ |
↑ |
= |
↑ |
↓ |
Before treatment, all animal models had significantly high Aβ and Hpf-tau levels and deteriorated cognition. Arrows indicate significant changes in each parameter tested after modulation of megalin levels. =, Impairment remains; miniMeg, miniMegalin; siMeg, siMegalin.
*p < 0.05 versus respective control (HIV)-injected animals, by Student's t test; **p < 0.05, one-way ANOVA followed by Student's t test; n = 6-8 animals per experimental group.