Table 1.

Octanol/water partition coefficients, brain uptakes at 2 and 30 min after injection in normal mice, K_i values for Aβ 1-42 fibrils, EC₅₀ values for Aβ 1-42, and tau fibrils from fluorescence assay of the compounds

	Octanol/water partition coefficient	Brain uptakes (%ID/g)			Ki values for Aβ fibrils (nm)	Fluorescence assay
			2 min	30 min			Ec50 for Aβ fibrils (nm)	EC50 for τ fibrils (nm)
BF-126	12.5	7.2 ± 0.49	0.16 ± 0.030	1.2 ± 0.68	1280 ± 1.64	583 ± 2.07
BF-158	47.4	11.3 ± 0.81	3.1 ± 0.61	>5000	659 ± 2.04	399 ± 2.41
BF-170	70.3	9.1 ± 1.2	0.25 ± 0.027	>5000	786 ± 1.79	221 ± 2.31
BF-168	62.6	3.9 ± 0.22a	1.6 ± 0.0071a	6.4 ± 1.0a	346 ± 2.21	1010 ± 1.72

Brain uptake and EC₅₀ values are shown as the mean ± SEM. K_i values for Aβ fibrils are shown as the mean ± SD.

^a From Okamura et al., 2004a.