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Developmental differences in the ability of kisspeptin to elicit LH release in vivo. Comparison of the LH response to kisspeptin-52 between P18 and adult male mice. Various doses of kisspeptin were administered into the lateral cerebral ventricle of the brain (intracerebroventricularly) of P18 and adult male mice (n = 6 per group). Serum was collected 30 min later. *p < 0.01 versus vehicle control; †p < 0.001 versus adult receiving 0.1 nmol. Error bars represent SEM.
