Table 2.
1H-MRSI Cre and Cho levels in the SNpc and striatum in MPTP-treated mice
|
|
|
|
Basal ganglia metabolites (mm)a |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cre |
Cho |
||||||||
| Treatment |
Day |
n
|
SNpc |
Striatum |
SNpc |
Striatum |
|||
| PBS | 2 | 16 | 10.5 ± 0.9 | 10.0 ± 0.3 | 2.2 ± 0.2 | 2.7 ± 0.1 | |||
| 6 | 10 | 10.7 ± 0.9 | 9.8 ± 0.6 | 2.3 ± 0.3 | 2.8 ± 0.1 | ||||
| MPTP | 2 | 4 | 11.6 ± 0.5 | 8.4 ± 0.7* | 1.9 ± 0.2 | 2.6 ± 0.2 | |||
| 6 | 8 | 11.5 ± 0.6 | 9.5 ± 0.9 | 2.7 ± 0.2 | 2.9 ± 0.2 | ||||
| MPTP/Cop-1 | 2 | 10 | 10.0 ± 0.6 | 10.6 ± 0.7 | 2.3 ± 0.2 | 2.7 ± 0.2 | |||
| 6 | 10 | 12.2 ± 1.2 | 10.4 ± 1.3 | 2.7 ± 0.3 | 3.2 ± 0.3 | ||||
| MPTP/OVA | 2 | 6 | 10.6 ± 0.8 | 8.9 ± 0.7 | 1.6 ± 0.3 | 2.6 ± 0.2 | |||
|
|
6 |
5 |
11.7 ± 1.1 |
9.6 ± 1.0 |
1.9 ± 0.1 |
2.7 ± 0.1 |
|||
Mean ± SEM for five to nine mice per group.
p = 0.03 compared with PBS-treated mice, day 2.