Table 3.
Stereological determination of TH+ dopaminergic (SNpc) and Nissl neurons coregistered by MRSI in each hemisphere at 6 d after MPTP treatment
|
|
Midbrain neuron counts per hemispherea |
||||||
|---|---|---|---|---|---|---|---|
| Entire SNpc |
MRSI voxel |
||||||
| Treatment |
THb
|
Nisslc
|
THb
|
Nisslc
|
|||
| PBS | 4881 ± 84 | 1598 ± 109 | 3025 ± 234 | 7517 ± 832 | |||
| MPTP | 2456 ± 200* | 1537 ± 210 | 2381 ± 189* | 7662 ± 385 | |||
| MPTP/Cop-1 | 3733 ± 221* | 2204 ± 151* | 2887 ± 263 | 8496 ± 347 | |||
| MPTP/OVA |
2991 ± 181*
|
1813 ± 244 |
1758 ± 237*
|
7027 ± 405 |
|||
a
Mean ± SEM for five to nine mice per group.
b
TH immunoreactive.
c
Nissl stained, TH negative.
*
p ≤ 0.05 compared with PBS-treated mice.