Figure 1.
Effect of suffusion of Aβ1-40 (5 μm) on the mouse somatosensory cortex with or without the NADPH oxidase peptide assembly inhibitor gp91ds-tat (gp91-ds) or its scrambled version (sgp91-ds). Aβ attenuates resting CBF (a) and reduces CBF responses to whisker stimulation (b), acetylcholine (c), the calcium ionophore A23187 (d), bradykinin (e), and the NO donor SNAP (f). Aβ did not alter the vasodilation produced by the NO-independent vasodilator adenosine (g). The cerebrovascular effects of Aβ were abrogated by pretreatment with gp91ds-tat but not sgp91-ds. LDU, Laser-Doppler perfusion units.*p < 0.05; ANOVA and Tukey's test; n = 6 per group. Error bars represent SEM.