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Effect of suffusion of Aβ1-40 (5 μm) on the somatosensory cortex of wild-type mice and mice lacking gp91phox, the catalytic subunit of NADPH oxidase. In gp91wt/wt, Aβ1-40 reduced resting CBF (a) and attenuated the increase in CBF elicited by whisker stimulation (b), acetylcholine (c), A23187 (d), and SNAP (e). Aβ1-40 was devoid of cerebrovascular effects in gp910/0. LDU, Laser-Doppler perfusion units. *p < 0.05; ANOVA and Tukey's test; n = 6 per group. Error bars represent SEM.
