Figure 6.
Effect of NOS inhibition on the cerebrovascular actions of Aβ peptides. The neuronal NOS inhibitor 7-NI attenuated resting CBF (a) and the CBF response to whisker stimulation (b) but not acetylcholine or adenosine (c, d). Application of Aβ1-40 after 7-NI did not further reduce resting CBF (a) or the responses to whisker stimulation (b). The absence of Aβ1-40 effects could not beat tributed to the fact that the response was already maximally attenuated, because the Na+ channel blocker TTX further attenuated the CBF response to whisker stimulation (b). LDU, Laser-Doppler perfusion units. *p < 0.05 from Ringer's solution; #p < 0.05 from 7-NI; ANOVA and Tukey's test; n = 6 per group. Error bars represent SEM.