Figure 2.

HFS of thalamic afferents induces input-specific LTP. A, Occlusion test. Electrical activation of thalamic (Thal) or BL afferents independently (left) or simultaneously (right; Thal + BL). Amplitude of EPSCs evoked by the paired stimuli (right) was virtually identical to the algebraic sum of EPSCs elicited by stimulating each site independently (dashed lines; left). B, C, Graph plotting the amplitude of EPSCs evoked by activation of thalamic (filled circles) or BL (empty circles) afferents (y-axis) as a function of time (x-axis). Thalamic HFS was applied at the time indicated by the downward arrow. Data were normalized to baseline response amplitudes. Traces above and below the graph in B show examples of responses evoked by activation of thalamic or BL afferents, respectively. The timing of these responses is indicated by the position of their peaks with respect to the x-axis of the graph just below. The data plotted in B were obtained in intact slices, where as the data depicted in C were obtained in slices in which CEm was disconnected from the basolateral complex by means of cuts (inset; dashed lines). Error bars represent SE.