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. 2005 Feb 16;25(7):1620–1628. doi: 10.1523/JNEUROSCI.4279-04.2005

Figure 1.

Figure 1.

Abbreviated ganglioside biosynthetic pathway. In the GalNAcT-/- mice, disruption of the β-1,4-N-acetylgalactosaminyl transferase gene (Unigene name, Galgt1) results in the absence of all of the complex gangliosides beyond GM3 and GD3 (Takamiya et al., 1996). In the GD3s-/- mice, disruption of the α-2,8-sialyl transferase II gene (Unigene name, Siat8a) results in the absence of b-series gangliosides and a compensatory overexpression of a-series gangliosides, including GD1a (Kawai et al., 2001; Okada et al., 2002). WT mice express varying levels of all gangliosides shown. Nomenclature is according to the IUPAC-IUB Joint Commission on Biochemical Nomenclature (1998) and Svennerholm (1994). CER, Ceramide; ○, galactose; □, N-acetylgalactosamine; •, glucose; ♦, N-acetylneuraminic acid/sialic acid. Carbon-carbon linkages are also shown.