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. 2005 Feb 16;25(7):1816–1825. doi: 10.1523/JNEUROSCI.4920-04.2005

Figure 4.

Figure 4.

GIP increases cell proliferation in the adult GCL. The density of BrdU-positive cells in the GCL was determined in rats that had been given intracerebroventricular PBS (A) or GIP (B). Quantification of BrdU-positive and Ki-67-positive cells (C) showed that GIP-treated animals exhibited 86% more BrdU-positive cells and 105% more Ki-67-positive cells than animals treated with PBS (control). Quantification of BrdU-positive cells in the GCL of Gipr-/- and wild-type (Wt+/+) mice (D) demonstrated that Gipr-/- mice only have ∼40% of the number of newborn cells compared with Wt+/+ mice. Means ± SEM are given. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bars: A, B, 100 μm.