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. 2005 Feb 16;25(7):1718–1729. doi: 10.1523/JNEUROSCI.4835-04.2005

Figure 6.

Figure 6.

NPY (1 μm) increased and BIIE0246 (100 nm) reduced the percentage of transmission failures during minimal electrical stimulation of recurrent mossy fibers. Additional data from these experiments are presented in Table 1. A, Effect of NPY. Top, The 10 consecutive traces (from a total of 50) shown are from a representative experiment. In this example, only 3 of the first 10 stimuli presented at a frequency of 0.2 Hz evoked a minimal EPSC (asterisk) before exposure to NPY. Bath application of NPY reduced the transmission rate to 1 of 10. Bottom, Grouped data (means ± SEM) from 10 granule cells demonstrated a significant increase in the percentage of response failures. *p < 0.01 by paired t test with respect to recordings made just before exposure to NPY. B, Effect of BIIE0246. Top, See A for details. In this example, BIIE0246 increased the transmission rate of minimal EPSCs from 3 of 10 to 5 of 10. Bottom, Grouped data (means ± SEM) from eight granule cells demonstrated a significant reduction in the percentage of response failures. *p < 0.01 by paired t test with respect to recordings made just before exposure to BIIE0246 (BIIE).