Figure 7.

NPY (1 μm) reduced and BIIE0246 (100 nm) increased the frequency of mEPSCs in granule cells from the status epilepticus group but not in granule cells from control rats. The traces shown are from representative experiments. Individual mEPSCs that met our criterion for analysis are indicated by asterisks. To the right of each set of traces is a cumulative probability plot for the time interval between identified mEPSCs. ○, Just before exposure to the test compound; •, during exposure to the test compound. Note that BIIE0246 shifted the plot to the left in the experiment from the status epilepticus group, consistent with a higher mEPSC frequency. NPY produced only a small change in the opposite direction. Neither compound affected the interevent interval in slices from control rats. Grouped data from these experiments are presented in Table 2.