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Inhibitors of CaMKK and MEK suppress LTP by a translation-dependent pathway. A, Mouse hippocampal slices were treated by bath application with the translation inhibitor anisomycin (Aniso; 40 μm) 30 min before and for the duration of recording after E-LTP (as in Fig. 2 D). n = 8. Note that the magnitude and kinetics of anisomycin suppression of LTP are identical to those of U0126 (UO; B) and STO-609 (STO; C) and are occluded by STO-609 (D). CTL, Control.
