Figure 5.

Delayed treatment with C3-07 promotes regeneration past the lesion site. A, Photographs of optic nerve sections immunostained with CTβ antibody to reveal axons regenerating distally to the lesion site (arrowheads) 2 weeks after microlesion in C3-07-treated animals and PBS controls. C3-07 or PBS was injected into the vitreous 4 d after optic nerve injury. Scale bar, 100 μm. B, Quantification of regeneration in C3-07-treated animals compared with controls. C, Comparison of average longest axon in each treatment group after an immediate or delayed treatment. ^**p < 0.01; ^*p < 0.05; Student's t test.