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. 2005 Feb 2;25(5):1249–1259. doi: 10.1523/JNEUROSCI.1786-04.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/251249-11.00/0

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Figure 5. — Regional differences in spontaneous and drug-induced motor activity in wild-type (+/+) and gephyrin-deficient (-/-) mice. A, An example of the differences in nerve burst activity from hypoglossal (XII) and lumbar (L5) ventral rootlets recorded from +/+ and -/- brainstem-whole spinal cords. B, Mean nerve burst frequency for L5 (+/+, n = 9; -/-, n = 7) and hypoglossal (+/+, n = 6; -/- n = 4) nerve recordings showing a significant decrease in lumbar nerve burst frequency and an increase in hypoglossal nerve burst frequency. C, Mean nerve activity per minute (calculated as total nerve burst charge per minute) for lumbar (+/+, n = 9; -/-, n = 7) and hypoglossal (+/+, n = 6; -/-, n = 4) nerve recordings, showing a significant decrease in lumbar mean nerve activity and an increase in hypoglossal nerve activity. ^*p < 0.05; ^**p < 0.01; Student's t test. Effects of glycine and GABA on nerve burst frequency are significantly different for lumbar and hypoglossal nerve activity in +/+ and -/- mice. Mean burst frequency during drug application is shown as a percentage of burst frequency for 10-20 min before drug application (indicated by dashed line and referred to in text as “control”). D, GABA (100 μm) application increases mean L5 burst frequency and decreases XII burst frequency in +/+ mice (white bars); these effects are enhanced in -/- mice (black bars). Two-way ANOVA; p < 0.05. E, Glycine (100 μm) application also increases mean lumbar burst frequency and decreases hypoglossal nerve burst frequency in +/+ mice (white bars); these effects are abolished in -/- mice (black bars). Two-way ANOVA; p < 0.05.