Table 1.
Clinical scores in the two stages of MPTP-induced parkinsonism
|
|
Clinical state |
||||||
|---|---|---|---|---|---|---|---|
| Asymptomatic |
Parkinsonian |
||||||
| Items |
Start |
End |
Start |
End |
|||
| Home-cage hypokinesia (mild/moderate/severe) | 1, 0, 1 | 0, 0, 0 | 3, 3, 3 | 3, 3, 3 | |||
| Rigidity (mild/moderate/severe) | 0, 0, 0 | 0, 0, 0 | 3, 2, 2 | 2, 2, 2 | |||
| Bradykinesia (mild/moderate/severe) | 0, 0, 0 | 0, 0, 0 | 3, 2, 2 | 3, 2, 3 | |||
| Tremor (mild/moderate/severe) | 0, 0, 0 | 0, 0, 0 | 3, 3, 3 | 2, 3, 2 | |||
| Feeding (reduced/impaired/impossible) | 0, 0, 0 | 0, 0, 0 | 3, 2, 3 | 3, 2, 3 | |||
| Freezing (some/frequent episodes) | 1, 0, 0 | 0, 0, 0 | 2, 2, 2 | 2, 2, 2 | |||
| Posture (some/persistent stooping) | 0, 0, 0 | 0, 0, 0 | 2, 2, 2 | 2, 2, 2 | |||
| Vocalization (reduced/absent) | 0, 0, 0 | 0, 0, 0 | 2, 2, 2 | 2, 2, 2 | |||
| Spontaneous eye movements (few/none) | 1, 0, 1 | 0, 0, 0 | 2, 2, 2 | 2, 2, 2 | |||
| Triggered eye movements (occasional/none) | 0, 0, 0 | 0, 0, 0 | 1, 1, 1 | 2, 1, 1 | |||
| Arm movements (slow/no movements) | 0, 0, 0 | 0, 0, 0 | 2, 1, 1 | 2, 1, 1 | |||
| Arm posture (flexed/dystonic) | 0, 0, 0 | 0, 0, 0 | 1, 1, 1 | 1, 1, 1 | |||
| Total |
3, 0, 2 |
0, 0, 0 |
27, 24, 23 |
27, 23, 23 |
|||
The scores at the start and at the end of the recording periods are given for monkeys F, R, and G, respectively. They are detailed according to Schneider and Kovelowski (1990), with a total ranging from 0 (normal) to 29 (full parkinsonism).