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. 2005 Feb 9;25(6):1354–1365. doi: 10.1523/JNEUROSCI.3034-04.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/251354-12.00/0

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Figure 4. — Axon recognition by oligodendrocytes in optic nerves and axonal degeneration in Olig1-null mutants. A-C, Intermediate filament-negative oligodendrocyte processes (arrows) contact (A) and begin to encircle (B, C) axons (A). Formation of a multilayer membrane flap (C, arrow) near an axon is also observed. These ultrastructural analyses indicate that oligodendrocytes recognize axons and begin the process of ensheathment in Olig1-null (-/-) mice. D, Myelin figures (arrows) within optic nerve axons from -/- mice. E, Axonal swellings and degenerating axons (arrows) are observed in optic nerves of -/- mice. F, High-power view of a degenerating axon (arrow) shown in E showing fragmented cellular organelles and mitochondria. Scale bars, 500 nm.