Table 1.
Quantitative analysis of myelin gene expression in the CNS of Olig1-heterozygous and -null mice
|
|
Mbpa |
Maga |
Plp1a |
Cgta |
Cnpa |
|---|---|---|---|---|---|
| Forebrain | |||||
| Olig1+/− | 0.3418 ± 0.1007 | 0.4258 ± 0.1153 | 0.7743 ± 0.1047 | 0.8471 ± 0.1448 | 0.4463 ± 0.0482 |
| Olig1−/− | 0.0005 ± 0.0003 | 0.0015 ± 0.0004 | 0.0029 ± 0.0007 | 0.0309 ± 0.0050 | 0.0456 ± 0.0006 |
| Fold change | 637 | 284 | 267 | 27 | 10 |
| Spinal cord | |||||
| Olig1+/− | 3.1043 ± 0.1475 | 2.4897 ± 0.7200 | 2.5285 ± 0.4615 | 2.6697 ± 0.5169 | 2.6840 ± 0.1880 |
| Olig1−/− | 0.1997 ± 0.0541 | 0.2733 ± 0.1505 | 0.1222 ± 0.0009 | 0.1718 ± 0.0031 | 0.2175 ± 0.0110 |
| Fold change |
15 |
9 |
20 |
15 |
12 |
a
Gene expression relative to internal control Gapdh. Data are expressed as means ± SD.