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. 2005 Dec 14;25(50):11595–11604. doi: 10.1523/JNEUROSCI.2837-05.2005

Figure 2.

Figure 2.

Targeted expression of a tauLacZ reporter integrated at the Brn3a locus. A, In the targeting strategy shown, integration of a tauLacZ reporter replaces the entire Brn3a coding sequence. The neomycin (Neo) resistance cassette is subsequently excised by crossing with a protamine-Cre deleter line. B, Expression of the tauLacZ transgene replicates all known sites of Brn3a expression in an E13.5 Brn3atauLacZ embryo. C, D, Colocalization of β-galactosidase (βgal) and Brn3a immunoreactivity in the retina of an E16.5 Brn3atLacZ embryo. E–H, Expression of the tauLacZ transgene in the adult brain at the level of the caudal thalamus (E, F) and at the level of the superior colliculus (G, H). 5g, Trigeminal ganglion; C, spinal cord; DRG, dorsal root ganglia; Hb, habenula; IP, interpeduncular nucleus; LG, lateral geniculate; opt, optictract; Mes, mesencephalon (deep gray); R, red nucleus; SC, superior colliculus. Scale bars: C, 200 μm; D, 50 μm; E, G, 1 mm.