Figure 6.

Effect of NE application on VRG rhythm produced in slices from wt and Mecp2-/y mice. A1, Integrated population activity from a wt slice preparation before application of NE. A2, In the same animal, exogenous application of NE (20 μm) increases the respiratory rhythmic frequency. B1, Integrated population activity from a Mecp2-/y mouse before application of NE. B2, Exogenously applied NE (20 μm) significantly increases the regularity and frequency of respiratory rhythmic activity. C, Examples of sequential cycle period histograms for a wt (C1), a Mecp2-/y mouse before NE application (C2), and the same Mecp2-/y mouse in the presence of NE (C3). Each histogram represents cycle period values (ordinate; seconds) calculated for 80 consecutive cycles (abscissa). Note that the cycles period values become more regular after adding NE.