Table 1.
Comparison of spontaneous IPSC properties in dLGN TC neurons under various experimental conditions
|
|
IPSC parameter |
|
|
|
|
|---|---|---|---|---|---|
| Experimental condition |
Peak amplitude (pA) |
Weighted decay time constant (ms) |
Frequency (Hz) |
Charge transfer (fC) |
Total current (pA) |
| Control (n = 21) | -54.8 ± 13.0 | 5.8 ± 1.4 | 6.7 ± 3.9 | -350.4 ± 142.1 | -2.4 ± 1.9 |
| 1 μm GABA (n = 9) | -61.0 ± 14.2 | 4.4 ± 1.0* | 4.4 ± 2.4 | -285.4 ± 46.5 | -1.2 ± 0.6 |
| 5 μm flurazepam (n = 10) | -61.3 ± 12.0 | 8.1 ± 1.9*** | 6.9 ± 1.6 | -541.1 ± 158.0** | -3.9 ± 1.8* |
| 10 nm THDOC (n = 12) | -50.5 ± 13.0 | 4.9 ± 0.9 | 7.0 ± 8.0 | -265.5 ± 91.3 | -1.9 ± 2.4 |
| 100 nm THDOC (n = 12) | -53.3 ± 14.8 | 7.7 ± 2.0* | 5.2 ± 2.1 | -456.0 ± 187.0 | -2.4 ± 1.5 |
| 100 nm THIP (n = 10) | -51.7 ± 12.9 | 4.9 ± 0.6 | 6.1 ± 2.7 | -267.4 ± 74.9 | -1.8 ± 1.1 |
| 200 nm GBZ (n = 7) | -35.8 ± 8.8** | 6.3 ± 2.1 | 1.4 ± 1.2** | -262.9 ± 130.3 | -0.4 ± 0.3** |
| 100 nm GBZ (n = 12) | -34.7 ± 5.0*** | 5.7 ± 1.3 | 1.7 ± 0.6*** | -236.8 ± 66.9* | -0.4 ± 0.2** |
| 50 nm GBZ (n = 18) | -43.4 ± 10.5** | 6.4 ± 1.3 | 3.3 ± 1.7** | -317.2 ± 123.5 | -1.1 ± 0.9* |
| 25 nm GBZ (n = 14) | -43.6 ± 7.1** | 5.6 ± 1.3 | 5.2 ± 2.7 | -273.1 ± 80.65 | -1.4 ± 0.9 |
| 50 nm GBZ + 1 μm GABA (n = 7) | -35.1 ± 6.5*** | 4.5 ± 1.0* | 3.3 ± 1.6* | -176.3 ± 55.6** | -0.6 ± 0.5* |
| 25 nm GBZ + 1 μm GABA (n = 6) |
-42.7 ± 5.3* |
3.9 ± 0.6** |
4.0 ± 1.9 |
-184. ± 126.0** |
-0.7 ± 0.2* |
Number of recorded neurons for each condition are in parentheses. Data are expressed as mean ± SD. Values significantly different from control are as indicated (*p < 0.05, **p < 0.01, ***p < 0.001, Student's unpaired t test).