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. 2005 Dec 14;25(50):11564–11576. doi: 10.1523/JNEUROSCI.3796-05.2005

Figure 8.

Figure 8.

Comparison of neuroblasts between genotypes and treatment (i.e., intrastriatal injection of vehicle QA). A, The distance (in micrometers) of the farthest lateral DCX-positive cell, with the morphology of a migrating neuroblast, from the anterior SVZ was measured from three to four sections and averaged. There was no difference in lateral migration between genotypes (F(1,20) = 0.111; p = 0.742). There was no genotype × treatment interaction effect (F(1,20) = 2.249; p = 0.149), suggesting that there was no difference between genotypes in upregulation of neuroblast migration with QA treatment. B, Numbers of DCX-positive cells in the striatum are greater in QA-treated mice compared with the vehicle-treated mice (F(1,20) = 22.898; p < 0.001) but the same between genotypes (F(1,20) = 0.003; p = 0.956). DCX-positive cells in the striatum were greater in QA-treated versus vehicle-treated animals only in WT mice (p < 0.005) but not in R6/2 mice (p = 0.441), suggesting that neurogenesis was upregulated only in WT mice. Data have been log transformed, bars show means, and error bars show means ± 1.0 SEM. NS, Not statistically significant (p > 0.05); the asterisk denotes statistical significance (p < 0.05).