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. 2005 Dec 14;25(50):11619–11627. doi: 10.1523/JNEUROSCI.2294-05.2005

Figure 1.

Figure 1.

Activity-dependent LTD in the NAc is blocked after a single in vivo exposure to THC but recovers after repeated treatment. A, Representative experiments showing blockade of activity-dependent LTD in the accumbens after a single in vivo exposure to THC (1d THC). Stimulation of PFCx afferents to the NAc (10 min at 13Hz) induced LTD of the fEPSP in vehicle-treated mice (sham) that was absent after a single in vivo exposure to THC (1d THC, 3 mg/kg). Averaged traces taken at the times indicated by numbers are shown in the insets. Calibration: 0.2 mV (y-axis), 10 ms (x-axis). B, Typical experiments and sample traces showing recovery of 13 Hz-induced LTD in the accumbens of mice treated in vivo with THC for 7 d (7d THC). Calibration: 0.2 mV (y-axis), 20 ms (x-axis). C, Summary data of all of the experiments performed: the LTD induced in the NAc by 10 min at 13Hz stimulation of PFCx afferents does not differ between mice treated for 7 d with THC (7d THC, n = 8) or vehicle (sham, n = 7, p > 0.05). D, Compensatory adaptation of LTD is apparent in response to long, but not short, cortical stimulation. The data show the summary of all of the experiments performed: LTD induced by a 5 min at 10 Hz tetanus did not recover in slices prepared from mice repeatedly exposed to THC (7d THC, n = 4) compared with vehicle-treated mice (sham, n = 3).