Skip to main content
. 2005 Dec 14;25(50):11619–11627. doi: 10.1523/JNEUROSCI.2294-05.2005

Figure 4.

Figure 4.

CB1Rs do not mediate activity-dependent LTD in the NAc of 1 week THC-treated mice. A, The CB1R antagonist SR141716A (SR-1; 1 μm) abolished 10 min at 13 Hz-induced LTD in the NAc of mice treated for 7 d with vehicle but not in the THC-treated group (*p < 0.05). Sample fEPSPs taken at the times indicated by numbers are shown in the insets. Calibration: 0.2 mV (y-axis), 20 ms (x-axis). B, Summary bar graph showing the effects of CB1R blockade on the LTD induced by 10 min at 13 Hz-stimulation of PFCx afferences in the NAc of vehicle-treated mice (*p < 0.05) and after repeated exposure to THC. C, Recovery of CB1R-mediated LTD in the NAc 1 week after repeated THC treatment. SR-1 (1 μm) abolished 10 min at 13 Hz-induced LTD in slices from animals taken 1 week after the last THC injection (*p < 0.05).