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. 2005 Feb 23;25(8):1935–1942. doi: 10.1523/JNEUROSCI.4707-04.2005

Figure 4.

Figure 4.

SGK3 mRNA expression in the hippocampus is upregulated during context-shock memory consolidation and reconsolidation. A, qPCR showed that SGK3 mRNA expression was upregulated in the hippocampus 1 h after contextual fear conditioning and 1 h after context-shock memory reactivation compared with the naive and T+25 group. B, SGK3 mRNA expression in the hippocampus in the T+1 group differed significantly from the expression in the Box and LI groups; the expression in both control groups did not differ significantly from that in the naive group. (The naive and T+1 groups are the same as in A.) C, SGK3 mRNA expression in the hippocampus did not significantly differ between the naive and Tone groups. Thus, the upregulation after conditioning was specific for the learned association. D, SGK3 mRNA expression in the hippocampus in the R+1 group differed significantly from the expression in the T+25 and Box R+1 groups. Thus, upregulation after reexposure was specific for context-shock memory reactivation (naive, T+25, and R+1 are the same as in A). Data are means ± SEM; *p < 0.05; **p < 0.01.