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. 2005 Feb 23;25(8):1894–1903. doi: 10.1523/JNEUROSCI.4654-04.2005

Figure 2.

Figure 2.

Mature olfactory sensory neurons and OB glomeruli are lost in lactosamine β3GnT1 null mice. a, 1B2 and OMP ICC analysis of P1 OE. 1B2 expression in sensory neurons (arrowheads) is virtually absent in β3GnT1 null mice. Residual 1B2 labeling of the luminal surface of the OE is mucin dependent and is not present in Core-2 O-glycan-deficient mice (data not shown). The number of OMP+ neurons is greatly reduced in null mice, indicating that lactosamine is required for maintenance of the majority of fully differentiated sensory neurons. NC, Nasal cavity; NS, nasal septum. Scale bar, 50 μm. b, Histochemical staining for PLAP activity and ICC analysis of 1B2 and OMP expression in coronal sections from P10OBs. In null mice, the number of glomeruli (arrows) is reduced, and most 1B2 reactivity is lost (arrowheads). Higher-magnification views of boxed areas, shown below each figure, demonstrate the severe loss of normal glomerular structures at this age. GL, Glomerular layer; NL, nerve layer. Scale bar, 200 μm.