Figure 3.

CB₁ receptor binding is unaltered and G-protein coupling is reduced in AD frontal cortex. a, Specific ³H-WIN55,212-2 (WIN) binding (n = 18 in each group). b, Representative ³H-WIN55212-2 binding saturation curves (n = 3 in each group). c, Basal ³⁵S-GTPγS binding (n = 18 in each group). d, WIN55,212-2-stimulated ³⁵S-GTPγS binding (n = 18; ^*p < 0.05 compared with controls; Student's t test). e, f, CB₁ (e) and CB₂ (f) expression (as detected by Western blot) in control and AD brain. OD, Optical density. Results are mean ± SEM of n = 18 in each group; ^*p < 0.05 compared with controls (Student's t test); representative blots are shown. Error bars represent SEM.