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. 2005 Feb 23;25(8):1979–1984. doi: 10.1523/JNEUROSCI.5132-04.2005

Figure 2.

Figure 2.

Persistent PKMζ phosphorylation is critical for an intermediate phase of LTP. A, Infusion of 5 μm ZIP reversed potentiation when applied 1 h after tetanization (filled circles). By 3 h after tetanization, the level of EPSP responses was significantly reduced compared with preapplication levels (p < 0.01) and was not significantly different from the nontetanized pathway (open circles). B, Infusion of 0.5 μm ZIP produced a significant reduction of the initial potentiation by 3 h after tetanization (p < 0.05); the level of potentiation at that time was significantly higher than the EPSPs from the nontetanized pathway (p<0.02). By 5 h after LTP induction, the two pathways were not significantly different. C, Infusion of 0.25 μm ZIP significantly reduced the initial potentiation by 3 h after tetanization (p < 0.02) but by 5 h had not completely reversed the EPSP potentiation to the level of the nontetanized pathway (p < 0.05). D, Infusion of 0.1 μm had no effect. No effect of the inhibitor was observed in the control pathways in any experiment; n = 5-6 for all experiments.