Skip to main content
. 2019 Apr 3;3:PO.18.00276. doi: 10.1200/PO.18.00276

FIG 2.

FIG 2.

Factors influencing human papillomavirus (HPV) circulating tumor DNA (ctDNA) levels. (A) Analysis of HPV16 and HPV33 ctDNA levels in patients with low tumor burden. Panels i to iii indicate remaining lymph nodes (N1) delineated in red. White arrows in panels iv and v indicate low-volume T1 and T2 primary tumors, respectively. (B) Relationship between HPV16 and HPV33 ctDNA in pretreatment samples and gross tumor volume. (C) Correlation between pretreatment levels of HPV measured by HPV16 droplet digital polymerase chain reaction (ddPCR) and HPV copy number per tumor genome. (D) Correlation between pretreatment levels of HPV measured by HPV16 ddPCR and product of HPV copy number and gross tumor volume. OPSCC, oropharyngeal squamous cell carcinoma; SCC, squamous cell carcinoma.