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. 2019 Jul 17;2(4):247–263. doi: 10.1021/acsptsci.9b00020

Figure 4.

Figure 4

Combination treatment displays additive mis-splicing rescue in HSALR DM1 mouse model. Splicing analysis of ES events determined via RNA-seq on HSALR mice treated with 600 mg kg–1 erythromycin (EM, green) or 10 mg kg–1 pafuramidine (PaF, blue) or a combination of both (EM+PaF, magenta) per oral administration daily for 14 days. (A) Dcaf6 exon12, (B) Ldb3 exon11, (C) Mpdz exon27, and (D) Wrd7 exon17 mis-slicing events displayed greater rescue with combination treatment. Mean % rescue ± standard deviation values are displayed below each graph.