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. 2019 Jul 17;2(4):247–263. doi: 10.1021/acsptsci.9b00020

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Copyright © 2019 American Chemical Society

This article is made available for a limited time sponsored by ACS under the ACS Free to Read License, which permits copying and redistribution of the article for non-commercial scholarly purposes.

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Combination treatment partially rescues myotonia in the HSA^LR DM1 mouse model. (A) Myotonia in the quadriceps muscle of HSA^LR mice treated with erythromycin (EM, green), pafuramidine (PaF, blue), or the combination (EM+PaF, magenta) determined via electromyography. (B) Immunofluorescence in quadriceps muscle of untreated (HSA^LR), erythromycin (HSA^LR + EM), pafuramidine (HSA^LR + PaF), and combination-treated (HSA^LR + EM + PaF) HSA^LR mice against chloride channel, Clcn1 (green). DAPI shown in blue.