. 2019 Jun 27;42(2):399–410. doi: 10.1590/1678-4685-GMB-2017-0279

Table 3. Cell death evaluation on mice’ kidneys and liver.

Experimental Groups	Liver		Kidneys
	Number of dead cells	Mean ± SE	Number of dead cells	Mean ± SE
LOT 1
NC	79	15.80 ± 1.24	73	14.60 ± 0.81
IR-04 12 mg/kg	148	29.60 ± 2.20^a*	138	26.60 ± 1.24^a*
IR-04 24 mg/kg	208	41.60 ± 0.81^a*	208	41.60 ± 0.92^a*
IR-04 48 mg/kg	261	52.20 ± 1.02^a*	256	51.20 ± 0.96^a*
LOT 2
DOX	550	110.00 ± 0.70^a*	546	109.20 ± 0.58^a*
+ IR-04 12 mg/kg	486	97.20 ± 0.37^b*	481	96.20 ± 0.58^b*
+ IR-04 24 mg/kg	516	103.20 ± 1.02^b*	511	102.20 ± 0.86^b*
+ IR-04 48 mg/kg	540	108.00 ± 0.54^b	535	107.00 ± 0.54^b*
LOT 3
CIS	552	110.40 ± 0.50^a*	547	109.40 ± 0.67^a*
+ IR-04 12 mg/kg	472	94.04 ± 0.87^c*	469	93.80 ± 1.11^c*
+ IR-04 24 mg/kg	533	106.60 ± 1.20^c*	522	104.40 ± 1.20^c*
+ IR-04 48 mg/kg	532	106.40 ± 1.36^c*	526	105.20 ± 1.65^c*
LOT 4
CYC	547	109.40 ± 0.40^a*	540	108.00 ± 0.54^a*
+ IR-04 12 mg/kg	474	94.80 ± 0.86^d*	472	94.40 ± 1.20d^*
+ IR-04 24 mg/kg	517	103.4 ± 0.81^d*	511	102.20 ± 0.70^d*
+ IR-04 48 mg/kg	526	105.20 ± 1.15^d*	522	104.40 ± 0.87^d*

SE: Standard error of the mean; NC: Negative control; DOX: Doxorubicin group; CIS: Cisplatin group; CYC: Cyclophosphamide group. ^aStatistically compared to the NC group; ^bStatistically compared to the DOX group; ^cStatistically compared to the CIS group; ^dStatistically compared to the CYC group; ^*statistically significant difference (p<0.05; ANOVA/t-Student).