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. 2019 Sep 4;14(9):e0221111. doi: 10.1371/journal.pone.0221111

Fig 4. Human UCB (hUCB) cells were localized and re-enhanced cytokine/chemokine expression in the injured side.

Fig 4

(A, B) Cytokine and chemokine expressions were determined at 5 weeks post-IR without treatment (PBS treated control) (A) or with hUCB cell treatment at 3 weeks post-IR (B). Data are shown as in Fig 2. The p values comparing between injured side and intact side were indicated. (C) Brain tissue sections at 24 hours after hUCB cell treatment for 3 weeks post-IR mice were immunohistochemically stained for human antigen HLA-ABC, visualized in green. Counterstaining with DAPI (in blue) was also performed. Merged images of the intact side and injured side of brain tissue were shown. Bars = 20 μm. Data are one of representative observations. (D) The effect of hUCB cell treatment of healthy mice was compared to un-treated (PBS) age- and treatment timing-matched mice as reference controls. Data are shown as mean of expression levels. The p value comparing between PBS treated and hUCB cell treated was indicated.