Table 3. Cox regression analysis of overall survival.
| Univariable | Multivariablea | |||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| miR-4483 (per 2 times) | 1.02 | (0.84–1.23) | 0.840 | |||
| miR-8089 (per 2 times) | 0.52 | (0.33–0.8) | 0.003 | 0.61 | (0.37–0.98) | 0.045 |
| miR-4755-3p (per 2 times) | 1.01 | (0.88–1.15) | 0.848 | |||
| miR-296-3p (per 2 times) | 1.00 | (0.74–1.34) | 0.993 | |||
| miR-575 (per 2 times) | 0.88 | (0.72–1.06) | 0.185 | |||
| miR-4710 (per 2 times) | 0.89 | (0.75–1.06) | 0.203 | |||
| miR-5698 (per 2 times) | 0.74 | (0.61–0.9) | 0.003 | 0.76 | (0.62–0.92) | 0.008 |
| miR-3160-5p (per 2 times) | 0.97 | (0.82–1.13) | 0.712 | |||
| Age (per 10 yr) | 0.70 | (0.56–0.87) | 0.002 | 0.71 | (0.56–0.88) | 0.002 |
| ER positive | 0.93 | (0.57–1.5) | 0.760 | |||
| PgR positive | 0.78 | (0.5–1.19) | 0.254 | |||
| HER2 positive | 0.65 | (0.32–1.29) | 0.218 | |||
| TNBC positive | 1.71 | (0.98–2.95) | 0.057 | 1.60 | (0.88–2.9) | 0.119 |
| Stage IV | 0.93 | (0.44–1.93) | 0.847 | |||
| ECOG PS ≥1 | 1.76 | (1.14–2.68) | 0.010 | 1.91 | (1.22–2.98) | 0.004 |
| No. of metastatic sites ≥3 | 1.62 | (1.04–2.48) | 0.029 | 1.62 | (1.01–2.58) | 0.043 |
| Presence of visceral disease | 1.00 | (0.54–1.83) | 0.988 |
a. adjusted for marginally associated factors (p < 0.1) in univariable analyses.
HR, hazard ratio; CI, confidence interval.