Table 1. Parameter values and initial conditions of the 2D model.

a.u: arbitrary unit. In 2d, by definition, a MC time unit is 100 Δt and one MC space unit is set by the interaction radius of IP₃R, i.e. $d_{{\text{IP}}_{\text{3}}\text{R}}=1.0\text{MC}$ space unit. δ, β, μ, γ, b₁, b₂ and b₃ are first order constants, in (MC time unit)⁻¹. Diffusion coefficients D_Ca and D_IP3 are expressed in (MC space unit)².(MC time unit)⁻¹ whereas α, a₁, a₂, a₃ are expressed in (MC space unit)².(MC time unit)⁻¹.

Parameter	Description	Value in 2d model
V	Cell volume	200 × 200 a.u.
IP3 dynamics
IP0	Initial IP3 number/conc.	15 molec.
DIP3	IP3 diffusion	10 a.u
Nplc	PLCδ number/conc.	1000 molec.
δ	PLCδ max rate	0.1 a.u
β	IP3 decay	0.01 a.u
Ca2+ dynamics
Ca0	Initial Ca2+ number/conc.	50 molec.
DCa	Ca2+ diffusion	varied
μ	Ca2+ flux through open IP3R	50 a.u
γ	cytosolic Ca2+ influx	50 a.u
α	Ca2+ decay rate	1.0 a.u
IP3R
$N_{{\text{IP}}_{\text{3}}\text{R}}$	IP3R number	1000 molec.
$d_{{\text{IP}}_{\text{3}}\text{R}}$	IP3R interact. distance	1 space unit
IP3R binding
a1	First Ca	1.0 a.u
a2	IP3	1.0 a.u
a3	Second Ca	0.1 a.u
IP3R dissociation
b1	First Ca	0.1 a.u
b2	IP3	0.1 a.u
b3	Second Ca	0.1 a.u